Science & Technology

At SeSaM-Biotech, we consider science as an essential component of our business. Dedicated to excellence, we believe that only through continuous R&D we can stay competitive on a rapidly growing market. We strive to offer innovative solutions to the problems protein engineering faces today. The first solution we proudly developed is SeSaM (Sequence Saturation Mutagenesis).

The Problem: Limited Diversity

There are many ways to generate diversity at the protein level. Classical methods either mimic nature or are based on synthetic chemistry. Both approaches have complementary advantages and disadvantages. For this reason the ideal method would combine the advantages of both, while eliminating the disadvantages.

The Solution: SeSaM

SeSaM combines the best out of nature and synthetic chemistry leading to the generation of 92.6% out of the potential diversity. Using SeSaM technology, enzyme variants with completely new properties can be generated. Moreover, the advantageous properties of different variants can be combined through SeSaM so that the desired objectives can be achieved faster. This is why SeSaM-Biotech is able to find quickly the desired enzyme according to customer’s specifications.

In this part of our website you will find everything about our platform technology: SeSaM and directed evolution and its methods: screening, cloning & expression and enzyme properties that we can characterize the evolved enzyme for. Furthermore, in BioScience 101, we offer an introduction to the field of protein engineering for those that do not have too much experience.